Structure of PDB 7tct Chain C

Receptor sequence
>7tctC (length=453) Species: 9606 (Homo sapiens) [Search protein sequence]
LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEET
GGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSW
SDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNT
LSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPV
ADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNT
TEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNG
DGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGT
QLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLR
SRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRA
QPV
3D structure
PDB7tct A general chemical principle for creating closure-stabilizing integrin inhibitors.
ChainC
Resolution2.501 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C E243 D245 D247 T250 E252 E243 D245 D247 T250 E252
BS02 CA C D297 N299 D301 R303 D305 D297 N299 D301 R303 D305
BS03 CA C D365 D367 D369 Y371 D373 D365 D367 D369 Y371 D373
BS04 CA C D426 D428 N430 Y432 D434 D426 D428 N430 Y432 D434
BS05 I1F C F160 Y190 L192 D224 S225 F231 F160 Y190 L192 D224 S225 F231
Gene Ontology
Cellular Component
GO:0008305 integrin complex

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7tct, PDBe:7tct, PDBj:7tct
PDBsum7tct
PubMed36113427
UniProtP08514|ITA2B_HUMAN Integrin alpha-IIb (Gene Name=ITGA2B)

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