Structure of PDB 7t3i Chain C

Receptor sequence

>7t3iC (length=578) Species: 209285 (Thermochaetoides thermophila)

RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLH
GPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAI
RLAPCLIFLDEIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKN
VVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLAD
DINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADH
LANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGF
STIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWG
PPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKS
SAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIG
ATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDA
DLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIE
PVITMEDWEKALNEVKPSVKDPEKYMHS

3D structure

• PDB: 7t3i Communication network within the essential AAA-ATPase Rix7 drives ribosome assembly.
• Chain: C
• Resolution: 4.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	T276 K316 K574	T84 K124 K382
BS02	ATP	C	R361 R362	R169 R170
BS03	ATP	C	D630 R659	D438 R467
BS04	ATP	C	V503 G504 G545 C546 G547 K548 T549 L550 N645 I677 G733 A734	V311 G312 G353 C354 G355 K356 T357 L358 N453 I485 G516 A517
BS05	ATP	C	I204 S245 G246 C247 G248 K249 T250 I380 G408 S409	I12 S53 G54 C55 G56 K57 T58 I188 G216 S217

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:1990275 preribosome binding

Biological Process

• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:7t3i, PDBe:7t3i, PDBj:7t3i
• PDBsum: 7t3i
• PubMed: 36090660
• UniProt: G0RZG1