Structure of PDB 7t22 Chain C

Receptor sequence
>7t22C (length=448) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVADDFYTRPHRHIFTEMA
RLQESGSPIDLITLAESLERQGQLDSVGGCAYLAELSKNTPSAANISAYA
DIVRERAVVREMISVANEIAEAGFDPQGRTSEDLLDLAESRVFKIAESRA
NKDEGPKNIADVLDATVARIEQLFQQPHDGVTGVNTGYDDLNKKTAGLQP
SDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSEQIMMRSL
ASLSRVDQTKIRTGQLDDEDWARISGTMGILLEKRNIYIDDSSGLTPTEV
RSRARRIAREHGGIGLIMIDYLQLMRVPALSDNRTLEIAEISRSLKALAK
ELNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEV
YHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYDDE
3D structure
PDB7t22 Sequence of conformation changes of DnaB helicase during DNA unwinding and priming in Escherichia coli
ChainC
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C T358 N386 R403 E404 S405 G406 T335 N363 R380 E381 S382 G383
BS02 ADP C P233 S234 M235 G236 K237 T238 R271 Q281 G455 Q456 P210 S211 M212 G213 K214 T215 R248 Q258 G432 Q433
BS03 ALF C P233 E262 P210 E239
BS04 MG C T238 E262 T215 E239
BS05 ADP C R442 N443 G444 P445 R419 N420 G421 P422
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:0043139 5'-3' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:0010212 response to ionizing radiation
GO:0031297 replication fork processing
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005829 cytosol
GO:0030894 replisome
GO:0033202 DNA helicase complex
GO:1990077 primosome complex
GO:1990100 DnaB-DnaC complex
GO:1990156 DnaB-DnaG complex
GO:1990158 DnaB-DnaC-DnaT-PriA-PriB complex
GO:1990159 DnaB-DnaC-DnaT-PriA-PriC complex
GO:1990160 DnaB-DnaC-Rep-PriC complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t22, PDBe:7t22, PDBj:7t22
PDBsum7t22
PubMed
UniProtP0ACB0|DNAB_ECOLI Replicative DNA helicase DnaB (Gene Name=dnaB)

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