Structure of PDB 7stz Chain C

Receptor sequence

>7stzC (length=540) Species: 9606 (Homo sapiens) [Search protein sequence]

DWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGV
FIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTD
QNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTI
LSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEG
LSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAP
NTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHV
AVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQE
ITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFE
HVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCE
RNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKP
KMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGV

3D structure

PDB

7stz Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography.

Chain

Resolution

2.95 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	BMA	C	E111 T206	E111 T206
BS02	BMA	C	P335 E336 T426	P335 E336 T426
BS03	BMA	C	S126 V127 E129	S126 V127 E129
BS04	BMA	C	T225 T316 T318	T225 T316 T318
BS05	CA	C	E11 E69 D100 Q101 D103 D136	E11 E69 D100 Q101 D103 D136
BS06	CA	C	E11 D67 E69 D103	E11 D67 E69 D103
BS07	CA	C	N102 N104 D134 D136 N143 D195	N102 N104 D134 D136 N143 D195
BS08	CA	C	N215 N217 D246 D248 A254 N304	N215 N217 D246 D248 A254 N304
BS09	CA	C	E232 E291 D325 V326 E328 D360	E232 E291 D325 V326 E328 D360
BS10	CA	C	N327 E358 Q365 D415	N327 E358 Q365 D415
BS11	CA	C	N435 N437 D462 D464 N468 D517	N435 N437 D462 D464 N468 D517
BS12	CA	C	E343 E397 D433 V434 D436 D464	E343 E397 D433 V434 D436 D464
BS13	CA	C	E343 D395 E397 D436	E343 D395 E397 D436
BS14	CA	C	E119 E182 D213 T214 D216 D248	E119 E182 D213 T214 D216 D248
BS15	CA	C	E119 D180 E182 D216	E119 D180 E182 D216
BS16	CA	C	E232 D289 E291 E328	E232 D289 E291 E328

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7stz, PDBe:7stz, PDBj:7stz
PDBsum	7stz
PubMed	36157596
UniProt	P12830\|CADH1_HUMAN Cadherin-1 (Gene Name=CDH1)

[Back to BioLiP]