Structure of PDB 7sol Chain C

Receptor sequence

>7solC (length=970) Species: 9606 (Homo sapiens)

MAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLS
EDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVV
LTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDT
TGEEPKEIFISNITQANPGIVTCLENHPHKLETGQFLTFREINGMTGLNG
SIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFESLERQLKH
PKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLA
TSISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTG
KFSPLCQWLYLEAADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKL
QNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNR
QFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFY
TKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLT
ESYNSHRDPPEEEIPFATLKSFPAAIEHTIQWARDKFESSFSHKPSLFNK
FWQTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFE
KYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFL
QNAAKLYATVYCIPFAEEDLSADALLNILSEVKIQEFKPSEDERNAIFQL
EKAILSNEATKSDLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPA
DRFKTKRIAGKIIPAIATTTATVSGLVALEMIKVTGGYPFEAYKNCFLNL
AIPIVVFTETTEVRKTKIRNGISFTIWDRWTVHGKEDFTLLDFINAVKEK
YGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKKYVDLTVSF
APDIDGDEDLPGPPVRYYFS

3D structure

• PDB: 7sol Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.
• Chain: C
• Resolution: 2.25001 Å

Enzymatic activity

• Enzyme Commision number: 6.2.1.45: E1 ubiquitin-activating enzyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AMP	C	G469 D497 K521 K544 V545 L568 D569 N570 T626	G411 D439 K463 K486 V487 L510 D511 N512 T568

Gene Ontology

Molecular Function

• GO:0004792 thiosulfate sulfurtransferase activity
• GO:0004839 ubiquitin activating enzyme activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0008641 ubiquitin-like modifier activating enzyme activity
• GO:0016779 nucleotidyltransferase activity
• GO:0016874 ligase activity
• GO:0019780 FAT10 activating enzyme activity

Biological Process

• GO:0006511 ubiquitin-dependent protein catabolic process
• GO:0007612 learning
• GO:0007626 locomotory behavior
• GO:0016567 protein ubiquitination
• GO:0021764 amygdala development
• GO:0021766 hippocampus development
• GO:0032446 protein modification by small protein conjugation
• GO:0036211 protein modification process
• GO:0060996 dendritic spine development

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7sol, PDBe:7sol, PDBj:7sol
• PDBsum: 7sol
• PubMed: 35986001
• UniProt: A0AVT1|UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 (Gene Name=UBA6)