Structure of PDB 7skm Chain C

Receptor sequence
>7skmC (length=300) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
AAATGTGKGVLGDTKDININSIDGGFSLEDLTHQGKLSAYNFNDQTGQAT
LITNEDENFVKDDQRAGVDANYYAKQTYDYYKNTFGRESYDNHGSPIVSL
THVNHYGGQDNRNNAAWIGDKMIYGDGDGRTFTNLSGANDVVAHELTHGV
TQETANLEYKDQSGALNESFSDVFGYFVDDEDFLMGEDVYTPGKEGDALR
SMSNPEQFGQPSHMKDYVYTEKDNGGVHTNSGIPNKAAYNVIQAIGKSKS
EQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
3D structure
PDB7skm Structural evidence for standard-mechanism inhibition in metallopeptidases from a complex poised to resynthesize a peptide bond.
ChainC
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.29: aureolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C Q317 N321 N322 V349 H352 E353 R408 H436 Q109 N113 N114 V141 H144 E145 R200 H228
BS02 CA C Y398 T399 K402 D405 Y190 T191 K194 D197
BS03 CA C D387 E389 D390 E395 D179 E181 D182 E187
BS04 CA C D348 D387 D390 L392 E395 D140 D179 D182 L184 E187
BS05 ZN C H352 H356 E376 H144 H148 E168
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7skm, PDBe:7skm, PDBj:7skm
PDBsum7skm
PubMed
UniProtP81177|AURE_STAAU Zinc metalloproteinase aureolysin (Gene Name=aur)

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