Structure of PDB 7sh2 Chain C

Receptor sequence
>7sh2C (length=325) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SKENLPWVEKYRPETLDEVYGQNEVITTVRKFVDEGKLPHLLFYGPPGTG
KTSTIVALAREIYGKNYSNMVLELNASDDRGIDVVRNQIKDFASTRQIFS
KGFKLIILDEADAMTNAAQNALRRVIERYTKNTRFCVLANYAHKLTPALL
SRCTRFRFQPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDMRRV
LNVLQSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAVLKSILEDDWGT
AHYTLNKVRSAKGLALIDLIEGIVKILEDYELQNEETRVHLLTKLADIEY
SISKGGNDQIQGSAVIGAIKASFEN
3D structure
PDB7sh2 DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp.
ChainC
Resolution3.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS C V16 Y19 R20 Y28 P55 G56 T57 G58 K59 T60 S61 N148 L169 R177 M205 R206 V8 Y11 R12 Y20 P47 G48 T49 G50 K51 T52 S53 N140 L161 R169 M197 R198
BS02 MG C T60 D117 T52 D109
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0005829 cytosol
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sh2, PDBe:7sh2, PDBj:7sh2
PDBsum7sh2
PubMed35314830
UniProtP38629|RFC3_YEAST Replication factor C subunit 3 (Gene Name=RFC3)

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