Structure of PDB 7sbn Chain C

Receptor sequence
>7sbnC (length=407) Species: 9606 (Homo sapiens) [Search protein sequence]
LPSLEDLLFYTIAEQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTL
QTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYE
SAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQS
CVKPLKYAIAVNDLGTEYVHRYVGKEPSGLKLFLNEDDKPHNPMVNAGAI
VVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNF
AIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGF
CPITGERVLSPEAVRNTLSLMHSCGMWDFSGQFAFHVGLPAKSGVAGGIL
LVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKK
LDPRREG
3D structure
PDB7sbn High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding.
ChainC
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLN C S286 N335 N388 Y414 V484 S150 N196 N249 Y275 V345
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sbn, PDBe:7sbn, PDBj:7sbn
PDBsum7sbn
PubMed34999118
UniProtO94925|GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (Gene Name=GLS)

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