Structure of PDB 7s6m Chain C

Receptor sequence
>7s6mC (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFS
CFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEASKKEKDKDSKLEKA
LKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGM
VFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPK
EFREISYLKKLKVKKQDRIFPP
3D structure
PDB7s6m Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C S16 A19 S20 K22 R34 F44 V48 S274 G275 S11 A14 S15 K17 R29 F39 V43 S137 G138
BS02 dna C E263 I266 F267 E338 E126 I129 F130 E201
BS03 ZN C C21 H53 C56 C16 H48 C51
BS04 ZN C C295 C298 C311 C321 C158 C161 C174 C184
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7s6m, PDBe:7s6m, PDBj:7s6m
PDBsum7s6m
PubMed35793673
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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