Structure of PDB 7s6d Chain C

Receptor sequence
>7s6dC (length=478) Species: 1836,324833 [Search protein sequence]
WRRRQREQSALDDLRYKVTWKPTAVADGASATGTWLVVVPESLAGGGWPV
VVARAVDQAGGRPVVLSVDAADGADRSRLGLRIHEALGEGPVPDAVVSLL
ALDPSALPGLPDVPQALASTAALVQALLDLGLEARLWCVTSGAVSVSGAD
GPSAPEQAAVWGFGRVAGLEHPHLWAGLVDLPPEADERTAARLVGVLAGA
GGEDQVALRSSGVFVRRLVRAPASEVPAVRSWKPGGTVLVTGGTGGLGRQ
VARWLARGGADHLLLVSRRGVDAPGADELVDELTDLGARVTVAACDVADR
DAVQRLLSEQVPSDAPLTAVIHTAAVLDDGVIDSLSPERMEQVLRVKVGG
AVHLYELTRESDLSAFVLFSSFGSTFGLPGLGNYAPGNAALEALAEQWRA
EGRPATAVGWGTWAGTHGIHELEPALATAALEQALERDESSPVIIDIDWE
RFAVAFHAKRPTRGFELVPEAQAALEAA
3D structure
PDB7s6d Modular polyketide synthase contains two reaction chambers that operate asynchronously.
ChainC
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.94: 6-deoxyerythronolide-B synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATR C G1210 G1211 S1232 R1233 R1234 V1262 A1290 V1311 G245 G246 S267 R268 R269 V297 A325 V346
Gene Ontology
Molecular Function
GO:0004312 fatty acid synthase activity
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0031177 phosphopantetheine binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:0033068 macrolide biosynthetic process
GO:0071770 DIM/DIP cell wall layer assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s6d, PDBe:7s6d, PDBj:7s6d
PDBsum7s6d
PubMed34735234
UniProtB6ZK67;
Q03132|ERYA2_SACER 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4 (Gene Name=eryA)

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