Structure of PDB 7s65 Chain C

Receptor sequence
>7s65C (length=463) Species: 32046 (Synechococcus elongatus) [Search protein sequence]
HQAIAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNGI
IEFDEPGVFVTFEETPQDIIKNARSFGWDLAKLVDEGKLFILDASPDPEG
QEVVGGFDLSALIERINYAIQKYRARRVSIDSVTSVFQQYDASSVVRREL
FRLVARLKQIGATTVMTTERIEEYGPIARYGVEEFVSDNVVILRNVLEGE
RRRRTLEILKLRGTSHMKGEYPFTITDHGINIFPLGAMRLTQRSSNVRVS
SGVVRLDEMCGGGFFKDSIILATGATGTGKTLLVSRFVENACANKERAIL
FAYEESRAQLLRNAYSWGMDFEEMERQNLLKIVCAYPESAGLEDHLQIIK
SEINDFKPARIAIDSLSALARGVSNNAFRQFVIGVTGYAKQEEITGLFTN
TSDQFMGADSHIEAITDTIILLQYVEIRGEMSRAINVFKMRGSWHDKAIR
EFMISDKGPDIKD
3D structure
PDB7s65 Coupling of distant ATPase domains in the circadian clock protein KaiC.
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP C K457 R459 S461 H463 K439 R441 S443 H445
BS02 ATP C F199 K224 L225 T228 H230 F185 K210 L211 T214 H216
BS03 ATP C T290 G291 G293 K294 T295 W331 I472 T276 G277 G279 K280 T281 W317 I454
BS04 ATP C S48 G49 G51 K52 T53 F90 I239 S34 G35 G37 K38 T39 F76 I225
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0007623 circadian rhythm
GO:0009649 entrainment of circadian clock
GO:0016310 phosphorylation
GO:0042752 regulation of circadian rhythm
GO:0042754 negative regulation of circadian rhythm
GO:0048511 rhythmic process
GO:0070297 regulation of phosphorelay signal transduction system

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Molecular Function
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Biological Process
External links
PDB RCSB:7s65, PDBe:7s65, PDBj:7s65
PDBsum7s65
PubMed35864165
UniProtQ79PF4|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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