Structure of PDB 7rn7 Chain C

Receptor sequence
>7rn7C (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
NSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYE
VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPV
DLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIET
3D structure
PDB7rn7 Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.56: caspase-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R64 H121 Q161 C163 R30 H87 Q127 C129
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7rn7, PDBe:7rn7, PDBj:7rn7
PDBsum7rn7
PubMed35059567
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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