Structure of PDB 7rml Chain C

Receptor sequence
>7rmlC (length=257) Species: 122586 (Neisseria meningitidis MC58) [Search protein sequence]
YAKEINALNNSLSDLDINVSFEFFPPKNEQMETMLWDSIHRLQTLHPKFV
SVTYRTHGIVKRIKQETGLEAAPHLTGIDASPIVALRGDEEKKPFYAEDL
VKLLRSVFDISVAAYPEVHPEAKSAQADLINLKRKIDAGANHVITQFFFD
VERYLRFRDRCVMLGIDVEIVPGILPVTNFKQLGKMAQVTNVKIPSWLSQ
MYEGLDDDQGTRNLVAASIAIDMVKVLSREGVKDFHFYTLNRSELTYAIC
HILGVRP
3D structure
PDB7rml Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase.
ChainC
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.54: methylenetetrahydrofolate reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C T57 Y58 H86 L115 R116 G117 D118 Y129 A130 A148 Y150 H154 A157 N166 K170 Y273 T53 Y54 H74 L86 R87 G88 D89 Y96 A97 A113 Y115 H119 A122 N131 K135 Y238
Gene Ontology
Molecular Function
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding
GO:0106312 methylenetetrahydrofolate reductase (NADH) activity
Biological Process
GO:0006555 methionine metabolic process
GO:0009086 methionine biosynthetic process
GO:0035999 tetrahydrofolate interconversion
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rml, PDBe:7rml, PDBj:7rml
PDBsum7rml
PubMed37165541
UniProtQ9JZQ3|METF_NEIMB 5,10-methylenetetrahydrofolate reductase (Gene Name=metF)

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