Structure of PDB 7rhq Chain C

Receptor sequence
>7rhqC (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
CGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERF
KELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLR
VTEGWDEHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYE
SKAHIHCSVKAENSVAAKSGG
3D structure
PDB7rhq Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex.
ChainC
Resolution3.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H134 H140 D147 H182 H108 H114 D121 H156
BS02 CA C E90 E126 D129 E67 E103 D106
BS03 CA C E89 E90 D95 T125 E126 E66 E67 D72 T102 E103
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:7rhq, PDBe:7rhq, PDBj:7rhq
PDBsum7rhq
PubMed35231446
UniProtQ15465|SHH_HUMAN Sonic hedgehog protein (Gene Name=SHH)

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