Structure of PDB 7rgd Chain C

Receptor sequence
>7rgdC (length=519) Species: 9606 (Homo sapiens) [Search protein sequence]
GHETAAQRYSARLLQAGYMADYLISGGTGYVPEDGLTAQQLFASADGLTY
NDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAM
ALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLE
AKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPR
IELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRD
YPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVY
QIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICI
TQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGAS
TVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMKVKIAQGVSGSI
QDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSA
QIEGGVHGLHSYTFLPFTK
3D structure
PDB7rgd IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
ChainC
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rgd, PDBe:7rgd, PDBj:7rgd
PDBsum7rgd
PubMed35013599
UniProtQ5H9Q6

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