Structure of PDB 7r0e Chain C

Receptor sequence

>7r0eC (length=729) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence]

MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWM
MAMKYPITADKRIMEMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWN
RNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPG
HADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKKELQDCKIAP
LMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEV
RNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVDILRQ
NPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQ
TLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGKDEQSIAEAIIV
AMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWG
IEPIDNVMGMIGILPDMTPSTEMSLRGVRVSKMERVVVSIDRFLRVRDQR
GNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWE
NVKIQWSQDPTMLYNKMEFEPFQSLVPKAARGQYSGFVRVLFQQMRDVLG
TFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRIVVRGNSPVFNY
NKATKRLTVLGKDAGALMEDPDEGTAGVESAVLRGFLILGKENKRYGPAL
SINELSNLAKGEKANVLIGQGDVVLVMKR

3D structure

PDB

7r0e Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.

Chain

Resolution

2.51 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	C	P43 R144 A156 Q160 R213 R216 Q257 N422 R423 H432 R436	P43 R144 A156 Q160 R213 R216 Q257 N422 R423 H432 R436
BS02	rna	C	G37 Q39 K41 W49 Y118 R216	G37 Q39 K41 W49 Y118 R216
BS03	GTA	C	I260 R264 Q306 F323 R355 H357 E361 F404 N429 H432 S519 T521	I260 R264 Q306 F323 R355 H357 E361 F404 N429 H432 S511 T513

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003968	RNA-dependent RNA polymerase activity

	Biological Process
GO:0001172	RNA-templated transcription
GO:0006351	DNA-templated transcription
GO:0006370	7-methylguanosine mRNA capping
GO:0019083	viral transcription
GO:0039523	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694	viral RNA genome replication
GO:0075526	cap snatching

	Cellular Component
GO:0033650	host cell mitochondrion
GO:0042025	host cell nucleus
GO:0044423	virion component

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7r0e, PDBe:7r0e, PDBj:7r0e
PDBsum	7r0e
PubMed	36596301
UniProt	X5F427

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