Structure of PDB 7qzu Chain C

Receptor sequence

>7qzuC (length=425) Species: 9606 (Homo sapiens)

ELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASR
SVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYR
PVAIALDTKGPGPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRA
ALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKV
FLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGA
DCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSR
DPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRS
AQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVG
DLVIVVTGWRPGSGYTNIMRVLSIS

3D structure

• PDB: 7qzu Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.
• Chain: C
• Resolution: 1.964 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.40: pyruvate kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FBP	C	L443 T444 T445 T446 S449 W494 R501 G526 R528 P529 G530 S531 Y533 T534	L325 T326 T327 T328 S331 W376 R383 G408 R410 P411 G412 S413 Y415 T416
BS02	OXL	C	K282 E284 A305 G307 D308 T340	K164 E166 A187 G189 D190 T222
BS03	MG	C	E284 D308	E166 D190
BS04	I4L	C	P65 N87 S89 H90 G91 Y95 G375 A378 K379	P47 N69 S71 H72 G73 Y77 G257 A260 K261

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003824 catalytic activity
• GO:0004743 pyruvate kinase activity
• GO:0030955 potassium ion binding

Biological Process

• GO:0006096 glycolytic process

External links

• PDB: RCSB:7qzu, PDBe:7qzu, PDBj:7qzu
• PDBsum: 7qzu
• PubMed: 35290845
• UniProt: P30613|KPYR_HUMAN Pyruvate kinase PKLR (Gene Name=PKLR)