Structure of PDB 7qy7 Chain C

Receptor sequence
>7qy7C (length=362) Species: 9606 (Homo sapiens) [Search protein sequence]
YLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYV
GEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTL
HKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPE
LFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKF
IGEGARMVRELFVMAREHAPSIIFMDSEVQRTMLELLNQLDGFEATKNIK
VIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTR
GINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKV
MQKDSEKNMSIK
3D structure
PDB7qy7 Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5
ChainC
Resolution4.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP C D281 R307 R310 D241 R267 R270
BS02 ATP C M150 I151 G152 P192 G193 T194 G195 L198 P320 I328 S355 G356 A357 M127 I128 G129 P169 G170 T171 G172 L175 P280 I288 S315 G316 A317
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0016887 ATP hydrolysis activity
GO:0031531 thyrotropin-releasing hormone receptor binding
GO:0036402 proteasome-activating activity
GO:0140296 general transcription initiation factor binding
GO:0140297 DNA-binding transcription factor binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0043069 negative regulation of programmed cell death
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qy7, PDBe:7qy7, PDBj:7qy7
PDBsum7qy7
PubMed37595557
UniProtP62195|PRS8_HUMAN 26S proteasome regulatory subunit 8 (Gene Name=PSMC5)

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