Structure of PDB 7qid Chain C

Receptor sequence
>7qidC (length=719) Species: 9606 (Homo sapiens) [Search protein sequence]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHG
CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQD
WRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLL
CTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNL
AAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSF
YALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKG
RQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDL
LGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG
WLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLD
PISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKG
LKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESS
FRKTFEDYLHNVVFVPRPS
3D structure
PDB7qid Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
ChainC
Resolution5.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C F714 V715 F714 V715
BS02 peptide C D535 P536 P537 N547 D535 P536 P537 N547
External links
PDB RCSB:7qid, PDBe:7qid, PDBj:7qid
PDBsum7qid
PubMed31727777
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

[Back to BioLiP]