Structure of PDB 7qh2 Chain C

Receptor sequence

>7qh2C (length=467) Species: 33952 (Acetobacterium woodii)

MNYKKVEASDIAAIKELIPAERVFVGTEIGEDFSHDELGSIHSYPEVLIK
VTSTEEVSKIMKYAYEHNIPVVVRGSGTGLVGACVPLFGGIMLETTLMNN
ILELDTENLTVTVEPGVLLMELSKFVEENDLFYPPDPGEKSATIAGNIST
NAGGMRAVKYGVTRDYVRGLTVVLANGEIIELGGKIVKNSSGYSLKDLVI
GSEGTLCVITKAILKLLPLPKMTLSLLIPFENISDAAGIVPKIIKSKAIP
TAIEFMERQTILFAEDFLGKKFPDSSSNAYILLTFDGNTKEQVEAEYETV
ANLCLAEGAKDVYIVDTVERKDSVWSARGAFLEAIKASTTEMDECDVVVP
RNRIAEFIEFTHDLAKEMDVRIPSFGHAGDGNLHIYVCRDELCQADWEAK
LAEAMDRMYAKALTFEGLVSGEHGIGYAKRKYLLNDFGTEHLALMAGIKQ
TFDPKNLLNPKKVCQMA

3D structure

• PDB: 7qh2 Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex.
• Chain: C
• Resolution: 2.43 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.436: lactate dehydrogenase (NAD(+),ferredoxin).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	C	V73 G75 S76 G77 T78 G79 L80 A83 C84 P137 G138 E139 A142 T143 G146 N147 S149 T150 A152 G153 E203 G204 I209 E422 H423	V73 G75 S76 G77 T78 G79 L80 A83 C84 P137 G138 E139 A142 T143 G146 N147 S149 T150 A152 G153 E203 G204 I209 E422 H423
BS02	FE	C	H377 H384 E422	H377 H384 E422

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0008720 D-lactate dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0050660 flavin adenine dinucleotide binding
• GO:0071949 FAD binding

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7qh2, PDBe:7qh2, PDBj:7qh2
• PDBsum: 7qh2
• PubMed: 35748623
• UniProt: H6LBS1|LCTD_ACEWD Lactate dehydrogenase (NAD(+),ferredoxin) subunit LctD (Gene Name=lctD)