Structure of PDB 7q45 Chain C

Receptor sequence
>7q45C (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]
TKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVT
VEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRH
ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGS
SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVAC
GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVC
QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKK
IVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEG
QKITRVACGSSHSVAWTT
3D structure
PDB7q45 Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of Myelin transcription factor 1
ChainC
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C L2966 D2968 S2978 K2979 K3002 R3161 A3214 K3231 Y3234 R3236 D3283 D3285 H3286 S3318 S3319 L8 D10 S20 K21 K44 R203 A256 K273 Y276 R278 D325 D327 H328 S360 S361
External links
PDB RCSB:7q45, PDBe:7q45, PDBj:7q45
PDBsum7q45
PubMed
UniProtO95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 (Gene Name=HERC2)

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