Structure of PDB 7q44 Chain C

Receptor sequence
>7q44C (length=369) Species: 9606 (Homo sapiens) [Search protein sequence]
RTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAV
TVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR
HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACG
SSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVA
CGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGV
CQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGK
KIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLE
GQKITRVACGSSHSVAWTT
3D structure
PDB7q44 Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of deubiquitinase USP35
ChainC
Resolution2.20008 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C L2966 D2968 S2978 K2979 K3002 R3161 A3214 Y3234 D3283 D3285 H3286 S3318 S3319 L9 D11 S21 K22 K45 R204 A257 Y277 D326 D328 H329 S361 S362
External links
PDB RCSB:7q44, PDBe:7q44, PDBj:7q44
PDBsum7q44
PubMed
UniProtO95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 (Gene Name=HERC2)

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