Structure of PDB 7q13 Chain C

Receptor sequence
>7q13C (length=590) Species: 9606 (Homo sapiens) [Search protein sequence]
LFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVE
LLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALER
WKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAH
FHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFN
VDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVT
PNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFI
AGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVE
TLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMM
KRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFH
PEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSIS
TNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQS
RRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFP
3D structure
PDB7q13 Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.
ChainC
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.11: glycogen(starch) synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G6P C H291 E292 H263 E264
BS02 G6P C Q294 H297 A298 K301 H501 R579 R582 R586 Q266 H269 A270 K273 H473 R551 R554 R558
BS03 UDP C K39 G41 G42 R331 F481 Y493 Y514 T515 E518 K11 G13 G14 R303 F453 Y465 Y486 T487 E490
BS04 GLC C H205 R211 V258 P511 W512 G513 Y514 H177 R183 V230 P483 W484 G485 Y486
Gene Ontology
Molecular Function
GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
GO:0005515 protein binding
GO:0005536 D-glucose binding
GO:0016757 glycosyltransferase activity
GO:0061547 glycogen synthase activity, transferring glucose-1-phosphate
Biological Process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0007507 heart development
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016234 inclusion body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7q13, PDBe:7q13, PDBj:7q13
PDBsum7q13
PubMed35835870
UniProtP13807|GYS1_HUMAN Glycogen [starch] synthase, muscle (Gene Name=GYS1)

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