Structure of PDB 7px0 Chain C

Receptor sequence

>7px0C (length=1252) Species: 7227 (Drosophila melanogaster)

AGRITINGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCV
CTLTGIHPETGELRTWAVNSCLTLLNTCLGLEVTTSEGLGNKRVGYHAIQ
QRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTMEEVENSFGGNICRCT
GYRPILDAMKSFAVDSNIQVPAECIDIEDLSTKKQQPKGSQLYPDGSRWS
WPVSLGDLFAALQGAVKEKLPYMLVAGNTAHGVYRRSPDIKAFIDVSGLA
ELKGHKLSADNSSLTLGGNLSLSETMELCRQLENTKGFEYLSQVWQHLDW
IANVPVRNAGTLAGNLSIKHAHPEFPSDVFIVLEALDAQVIVQEAVDKQQ
TVSLASYLGSSMEGKIIRGLVLRAYPKERFAFDSYKIMPRAQNAHAYVNA
AFLVEFTADAKVKSARICFGGIHPEFVHATAIENLIRDKNPFENGLVEKA
FGQLSTLLQPDAVLPDASPVYRRKLACGLFYKFLLKIAAQRKQGLGSRFV
TGGSLLKRPVSSGQQSFETFQEHYPVTKATEKHEGLIQCSGEATYSNDLP
TQHNQLWAAFVIAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVG
PKIRDQFFFPKDEELFATGEIKFYGQPVGIILANSNSLANRAAELVKLTY
EGGAEEILPSLKAVLDKVNKRLEQPIKSTIDVLQLEEPFDVSSSGQLDMG
LQYHYYMEPQTTVVLPFEGGLQVYAATQWMDLTQDTIANVLNLKSNDVQV
KTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKR
WAFHCDYDFFVQKSGKISGIVSRFYEDAGYLANESPIGHTVLLSKNCYEF
SDNYKLDGYLVCTDSPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPAD
VRFANLLPAHKMGDMMPRFLESTKYRERKAEAIAHNKENRWHKRGLGLCI
MEYQIGYFGQYPATVAIYHSDGTVVVSHGGIEMGQGMNTKISQVAAHTLG
IPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLNERLKPVR
EEVKPENWQDLIQEAYNRKINLIASDQCKQGDMDPYSVCGLCLTEVELDV
LTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPK
TGECLTNRTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAIC
LSIAVAFALQQALQSARDDAGVPKSWVTLTAPMTPEHLVLHSGTEPSQFK
LN

3D structure

• PDB: 7px0 Drosophila melanogaster's Aldehyde Oxidase 1: The First Invertebrate AOX structure
• Chain: C
• Resolution: 2.2 Å

Enzymatic activity

• Enzyme Commision number: 1.2.3.8: pyridoxal oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FES	C	Q111 C112 G113 C115 C148 C150 M728	Q110 C111 G112 C114 C147 C149 M707
BS02	FES	C	F40 C42 Q43 G45 C47 G48 C50 C72	F39 C41 Q42 G44 C46 G47 C49 C71
BS03	FAD	C	G45 M238 L239 A241 G242 N243 T244 A245 V248 N284 I316 A317 V321 G325 T326 A328 G329 N330 S332 I333 F340 S342 D343 I381 I382 K401 W1181	G44 M223 L224 A226 G227 N228 T229 A230 V233 N269 I301 A302 V306 G310 T311 A313 G314 N315 S317 I318 F325 S327 D328 I366 I367 K386 W1160

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004031 aldehyde oxidase activity
• GO:0004732 pyridoxal oxidase activity
• GO:0005506 iron ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0050660 flavin adenine dinucleotide binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0071949 FAD binding

Biological Process

• GO:0042817 pyridoxal metabolic process

Cellular Component

• GO:0005777 peroxisome
• GO:0005829 cytosol

External links

• PDB: RCSB:7px0, PDBe:7px0, PDBj:7px0
• PDBsum: 7px0
• UniProt: Q9VF53