Structure of PDB 7pw9 Chain C

Receptor sequence
>7pw9C (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
AKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKS
MVMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFL
DTQPILSPSILDHLINNYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWF
TDLSLYRFLQTAEMVKPSTEYYPHLVFLQNKARREDFCPRKLRQMHLMID
QLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDFSLLPGY
RGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRKSS
ALAEYSRLL
3D structure
PDB7pw9 Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
ChainC
Resolution3.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP C Q213 G214 T215 G216 K217 M219 A240 Q241 K246 T253 N372 Q45 G46 T47 G48 K49 M51 A72 Q73 K78 T85 N180
Gene Ontology
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

View graph for
Biological Process
External links
PDB RCSB:7pw9, PDBe:7pw9, PDBj:7pw9
PDBsum7pw9
PubMed34698635
UniProtQ9H0W8|SMG9_HUMAN Nonsense-mediated mRNA decay factor SMG9 (Gene Name=SMG9)

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