Structure of PDB 7pw8 Chain C

Receptor sequence
>7pw8C (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSM
VMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLD
TQPILSPSILDHLINNYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFT
DLSLYRFLQTAEMVKPSTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQ
LMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDPLFSLLPG
YRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRKS
SALAEYSRLL
3D structure
PDB7pw8 Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
ChainC
Resolution2.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP C Q213 G214 G216 K217 M219 Q233 A240 Q241 K246 Q252 T253 P272 N372 K373 M434 Q44 G45 G47 K48 M50 Q64 A71 Q72 K77 Q83 T84 P103 N179 K180 M241
BS02 MG C S218 T253 S49 T84
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001654 eye development
GO:0001701 in utero embryonic development
GO:0007420 brain development
GO:0007507 heart development
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:7pw8, PDBe:7pw8, PDBj:7pw8
PDBsum7pw8
PubMed34698635
UniProtQ9H0W8|SMG9_HUMAN Nonsense-mediated mRNA decay factor SMG9 (Gene Name=SMG9)

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