Structure of PDB 7pw5 Chain C

Receptor sequence
>7pw5C (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSM
VMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLD
TQPILSPSILDHLINNYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFT
DLSLYRFLQTAEMVKPSTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQ
LMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDPLFSLLPG
YRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRKS
SALAEYSRLL
3D structure
PDB7pw5 Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
ChainC
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP C Q213 G214 G216 K217 M219 Q233 A240 Q241 K246 T253 P272 N372 F433 M434 Q44 G45 G47 K48 M50 Q64 A71 Q72 K77 T84 P103 N179 F240 M241
BS02 MG C S218 T253 S49 T84
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001654 eye development
GO:0001701 in utero embryonic development
GO:0007420 brain development
GO:0007507 heart development
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:7pw5, PDBe:7pw5, PDBj:7pw5
PDBsum7pw5
PubMed34698635
UniProtQ9H0W8|SMG9_HUMAN Nonsense-mediated mRNA decay factor SMG9 (Gene Name=SMG9)

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