Structure of PDB 7pvj Chain C

Receptor sequence
>7pvjC (length=541) Species: 6279 (Brugia malayi) [Search protein sequence]
LADAVFKSACEERILLAYPDMTKVVNLFSKYNETVNTVRVSNDAVKDILE
IVGWPSMPLIFVKGNCCGFKELYQLEESGFLNEWLKEHEYDLAIVGGGSG
GLAAAKEAVRLGKKVVCLDFVKPSAMGTTWGLGGTCVNVGCIPKKLMHQA
ALLGEYIEDAKKFGLNWHQLKNAVQNHIASLNWGYRVQLKEKSVTYMNSY
ATFTGSHELSVKNKKGKVEKVTADRFLIAVGLRPRFPGALECCISSDDLF
SLPYNPGKTLCVSYVSLECAGFLKGIGNDVTVMVRSVLLRGFDQDMAERI
KKHMTERGVKFVQKYERLKKPTDSEPGMIRVHVTEDFNTVLMAIGRDAMT
DDLGLDVVGVNRAKSGKIIGRREQSVSCPYVYAIGDVLYGSPELTPVAIQ
AGKVLMRRLFTGSSELTEYDKIPTTVFTPLEYGSCGLSEYSAIQKYGKEN
INVYHNVFIPLEYAVTERKEKTHCYCKLICLKNEQDLILGFHILTPNAGE
ITQGFAIALKFDAKKADFDRLIGIHPTVAENFTTLTLVKED
3D structure
PDB7pvj Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus.
ChainC
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C V112 G115 S116 G117 D136 F137 T152 C153 G157 C158 K161 Y226 A227 V256 G257 Y295 V296 R392 D432 E439 T441 V95 G98 S99 G100 D119 F120 T135 C136 G140 C141 K144 Y200 A201 V230 G231 Y264 V265 R346 D386 E393 T395
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0045454 cell redox homeostasis

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Molecular Function
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Biological Process
External links
PDB RCSB:7pvj, PDBe:7pvj, PDBj:7pvj
PDBsum7pvj
PubMed35276442
UniProtA0A1I9G0T9

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