Structure of PDB 7put Chain C

Receptor sequence
>7putC (length=540) Species: 6279 (Brugia malayi) [Search protein sequence]
ADAVFKSACEERILLAYDMTKVVNLFSKYNETVNTVRVSNDAVKDILEIV
GWPSMPLIFVKGNCCGGFKELYQLEESGFLNEWLKEHEYDLAIVGGGSGG
LAAAKEAVRLGKKVVCLDFVKPSAMGTTWGLGGTCVNVGCIPKKLMHQAA
LLGEYIEDAKKFGWEIPEGNWHQLKNAVQNHIASLNWGYRVQLKEKSVTY
MNSYATFTGSHELSVKNKKGKVEKVTADRFLIAVGLRPRFPDVPGALECC
ISSDDLFSLPYNPGKTLCVYVSLECAGFLKGIGNDVTVMVRLRGFDQDMA
ERIKKHMTERGVKFVQYERLKKPTDSEPGMIRVHTEDNTVLMAIGRDAMT
DDLGLDVVGVNRAKSGKIIGRREQSVSCPYVYAIGDVLYGSPELTPVAIQ
AGKVLMRRLFTGSSELTEYDKIPTTVFTPLEYGSCGLSEYSAIQKYGKEN
INVYHNVFIPLEYAVTERKEKTHCYCKLICLKNEQDLILGFHILTPNAGE
ITQGFAIALKFDAKKADFDRLIGIHPTVAENFTTLTLVKE
3D structure
PDB7put Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus.
ChainC
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C V112 G115 S116 G117 D136 F137 V138 T152 C153 G157 C158 K161 Y226 V256 G257 Y295 R392 G431 D432 L440 T441 V94 G97 S98 G99 D118 F119 V120 T134 C135 G139 C140 K143 Y204 V234 G235 Y270 R346 G385 D386 L394 T395
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0045454 cell redox homeostasis

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Molecular Function
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Biological Process
External links
PDB RCSB:7put, PDBe:7put, PDBj:7put
PDBsum7put
PubMed35276442
UniProtA0A1I9G0T9

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