Structure of PDB 7phf Chain C

Receptor sequence
>7phfC (length=328) Species: 1924,1950,1114943 [Search protein sequence]
IDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPE
ALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRAWHDLTQAV
ARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLMTTR
EDTAFAAPAAAYDWTNVRHVLDVGGGNGGFAAAIARRAPHVSATVLEMAG
TVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDA
VRILTRCAEALEPGGRILIHEDRFFSTLLDLRMLVFLGGALRTREKWDGL
AASAGLVVEEVRGPLVPLDSCLLVLAPA
3D structure
PDB7phf Evolution-inspired engineering of anthracycline methyltransferases.
ChainC
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.292: carminomycin 4-O-methyltransferase.
4.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH C Y143 R153 F156 R163 F168 G187 E210 M211 G236 D237 F238 S252 F253 Y130 R140 F143 R150 F155 G174 E197 M198 G223 D224 F225 S239 F240
BS02 VAK C W106 F156 M160 R163 F253 L302 L303 R306 M307 F310 P345 L346 W93 F143 M147 R150 F240 L278 L279 R282 M283 F286 P317 L318
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7phf, PDBe:7phf, PDBj:7phf
PDBsum7phf
PubMed36874276
UniProtI2N5E8;
Q06528|DNRK_STRPE Carminomycin 4-O-methyltransferase DnrK (Gene Name=dnrK);
Q54527|RDMB_STREF Aclacinomycin 10-hydroxylase RdmB (Gene Name=rdmB)

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