Structure of PDB 7ovo Chain C

Receptor sequence
>7ovoC (length=389) Species: 10090 (Mus musculus) [Search protein sequence]
ESAPRIMRLVAECSRSGARAGELRLPHGTVATPVFMPVGTQATMKGITTE
QLDSLGCRICLGNTYHLGLRPGPELIRKAQGLHGFMNWPHNLLTDSGGFQ
MVSLFSLSEVTEEGVHFRSPYDGEETLLSPERSVEIQNALGSDIIMQLDH
VVSSTVTGPLVEEAMHRSVRWLDRCIAAHKHPDKQNLFAIIQGGLNADLR
TTCLKEMTKRDVPGFAIGGLSGGESKAQFWKMVALSTSMLPKDKPRYLMG
VGYATDLVVCVALGCDMFDCVRTARFGSALVPTGNLQLKKKQYAKDFSPI
NPECPCPTCQTHSRAFLHALLHSDNTTALHHLTVHNIAYQLQLLSAVRSS
ILEQRFPDFVRNFMRTMYGDHSLCPAWAVEALASVGIML
3D structure
PDB7ovo Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
ChainC
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.64: tRNA-guanosine(34) queuine transglycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QEI C F109 Q110 D159 V161 S164 G228 G229 L230 G232 M259 F99 Q100 D149 V151 S154 G218 G219 L220 G222 M249
BS02 ZN C C317 C319 C322 H348 C304 C306 C309 H335
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0032473 cytoplasmic side of mitochondrial outer membrane
GO:0032991 protein-containing complex
GO:0120507 tRNA-guanine transglycosylase complex
GO:1990234 transferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ovo, PDBe:7ovo, PDBj:7ovo
PDBsum7ovo
PubMed35815944
UniProtQ9JMA2|TGT_MOUSE Queuine tRNA-ribosyltransferase catalytic subunit 1 (Gene Name=Qtrt1)

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