Structure of PDB 7opp Chain C

Receptor sequence
>7oppC (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
HMSFLTEEEQEAIMKVLQRDAALKRAEEEGDYDYLIKFLALGDSGVGKTS
VLYQYTDGKFNSKFITTVGIDFREKRVVYRASTGRGQRIHLQLWDTAGLE
RFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYSENPDIV
LCGNKSDLEDQRVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEMLLD
LIMKRMERS
3D structure
PDB7opp Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
ChainC
Resolution2.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP C S18 G19 G21 K22 T23 S24 F34 S36 F38 T40 T41 G77 N133 K134 D136 L137 S163 A164 S44 G45 G47 K48 T49 S50 F60 S62 F64 T66 T67 G98 N154 K155 D157 L158 S184 A185
BS02 MG C T23 T41 T49 T67
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0031267 small GTPase binding
Biological Process
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:7opp, PDBe:7opp, PDBj:7opp
PDBsum7opp
PubMed35308027
UniProtP51159|RB27A_HUMAN Ras-related protein Rab-27A (Gene Name=RAB27A);
Q9HCH5

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