Structure of PDB 7onb Chain C

Receptor sequence
>7onbC (length=816) Species: 9606 (Homo sapiens) [Search protein sequence]
SPEEQKERKIMKLLLKIKNGTPMRKAALRQITDKAREFGAGPLFNQILPL
LMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYY
ARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASA
LGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVE
IIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQH
RGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIV
LKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTV
ELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKL
EEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLW
RLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPE
VLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDL
VGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAI
GPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRV
PELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTA
SAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLR
VAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIY
NDDKNTYIRYELDYIL
3D structure
PDB7onb Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors.
ChainC
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C M1056 K1086 A1087 I1088 G1089 P1090 H1091 D1092 M568 K598 A599 I600 G601 P602 H603 D604
BS02 rna C P1257 A1258 P769 A770
BS03 SJT C L1066 K1067 R1074 L578 K579 R586
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7onb, PDBe:7onb, PDBj:7onb
PDBsum7onb
PubMed34301950
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

[Back to BioLiP]