Structure of PDB 7oak Chain C

Receptor sequence
>7oakC (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
VLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS
TEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVK
RADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENS
APVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGC
GVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRR
MLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRK
3D structure
PDB7oak Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
ChainC
Resolution2.23 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 C146 G162 T182
Catalytic site (residue number reindexed from 1) D136 K138 C141 G157 T177
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V6B C I18 G19 V26 A39 F93 M94 D95 G96 C146 L148 G161 G162 I13 G14 V21 A34 F88 M89 D90 G91 C141 L143 G156 G157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7oak, PDBe:7oak, PDBj:7oak
PDBsum7oak
PubMed34543009
UniProtO14936|CSKP_HUMAN Peripheral plasma membrane protein CASK (Gene Name=CASK)

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