Structure of PDB 7o5l Chain C

Receptor sequence

>7o5lC (length=413) Species: 1111708 (Synechocystis sp. PCC 6803 substr. Kazusa)

KYDIKDISLAPQGRQRIEWAAREMPVLKQIRERFAQEKPFAGIRLVACCH
VTTETANLAIALHAGGADSLLIASNPLSTQDDVAACLVADYGIPVYAIKG
EDNETYHRHVQIALDHRPNIIIDDGSDVVATLVQERQHQLSDIIGTTEET
TTGIVRLRAMFNDGVLTFPAMNVNDADTKHFYDNRYGTGQSTLDGIIRAT
NILLAGKTIVVAGYGWCGKGVAMRAKGMGADVIVTEISPVPAIEAAMDGF
RVMPMAEAAHQGDIFITVTGNKHVIRPEHFAVMKDGAIVCNSGHFDIEID
LKSLKEQAKEVKEVRNFTEQYILPNGKSIIVIGEGRLVNLAAAEGHPSAV
MDMSFANQALACEHLVKNKGQLEPGMHSIPVEVDQEIARLKLQAMGIAID
SLTPEQVEYINSW

3D structure

• PDB: 7o5l Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803.
• Chain: C
• Resolution: 1.74 Å

Enzymatic activity

• Enzyme Commision number: 3.13.2.1: adenosylhomocysteinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	C	T158 T159 T160 N192 G221 G223 W224 C225 E244 I245 V276 T277 N279 S300 G301 N347	T150 T151 T152 N184 G213 G215 W216 C217 E236 I237 V268 T269 N271 S292 G293 N339
BS02	RB	C	L348 A349 A351	L340 A341 A343
BS03	RB	C	Y417 S420	Y409 S412
BS04	ADN	C	H58 T60 D132 E157 T158 K187 D191 L345 H354 M359	H50 T52 D124 E149 T150 K179 D183 L337 H346 M351

Gene Ontology

Molecular Function

• GO:0004013 adenosylhomocysteinase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006730 one-carbon metabolic process
• GO:0033353 S-adenosylmethionine cycle
• GO:0071269 L-homocysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7o5l, PDBe:7o5l, PDBj:7o5l
• PDBsum: 7o5l
• PubMed: 35775986
• UniProt: P74008|SAHH_SYNY3 Adenosylhomocysteinase (Gene Name=ahcY)