Structure of PDB 7ni1 Chain C

Receptor sequence
>7ni1C (length=464) Species: 9606 (Homo sapiens) [Search protein sequence]
NCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQ
INALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPF
DNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATE
LKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTY
RSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSR
VFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRI
GLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARK
LMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFW
WENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVN
CSTLPALNLASWRE
3D structure
PDB7ni1 Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
ChainC
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.2.2: myeloperoxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM C E242 M243 T329 F332 R333 G335 H336 I339 F407 L417 R424 E129 M130 T216 F219 R220 G222 H223 I226 F294 L304 R311
BS02 CA C T168 F170 D172 S174 T55 F57 D59 S61
BS03 UEB C R239 F366 F407 V410 M411 R126 F253 F294 V297 M298
BS04 BMA C F439 K505 F326 K392
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0020037 heme binding
Biological Process
GO:0006979 response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:7ni1, PDBe:7ni1, PDBj:7ni1
PDBsum7ni1
PubMed36005476
UniProtP05164|PERM_HUMAN Myeloperoxidase (Gene Name=MPO)

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