Structure of PDB 7nbq Chain C

Receptor sequence
>7nbqC (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
FTSKDTYLSHFNPRDYLEKYYKSAESQILKHLLKNLFKIFCLDGVKGDLL
IDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAFDWSP
VVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADC
VLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQ
KFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARK
L
3D structure
PDB7nbq Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.
ChainC
Resolution2.479 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.1: nicotinamide N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH C Y11 Y20 Y25 G63 S64 T67 Y69 D85 Y86 N90 D142 V143 T163 L164 C165 A169 Y7 Y16 Y21 G54 S55 T58 Y60 D76 Y77 N81 D133 V134 T154 L155 C156 A160 BindingDB: IC50=35300nM
BS02 U72 C Y20 L164 A198 S201 Y204 S213 Y242 A247 Y16 L155 A189 S192 Y195 S204 Y233 A238
Gene Ontology
Molecular Function
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0030760 pyridine N-methyltransferase activity
Biological Process
GO:0006769 nicotinamide metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0031100 animal organ regeneration
GO:0032259 methylation
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0045722 positive regulation of gluconeogenesis
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:7nbq, PDBe:7nbq, PDBj:7nbq
PDBsum7nbq
PubMed33668468
UniProtP40261|NNMT_HUMAN Nicotinamide N-methyltransferase (Gene Name=NNMT)

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