Structure of PDB 7n9h Chain C

Receptor sequence

>7n9hC (length=422) Species: 9606 (Homo sapiens) [Search protein sequence]

NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYF

3D structure

PDB

7n9h Determinants for TDP-43 Nuclear Localization Signal recognition and regulation by the importin alpha/beta heterodimer

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	W142 N146 S149 G150 T151 T155 W184 N188 D192 W231 R238 K240 D270 W273 G281 N283 V321 T322 G323 W357 N361 A364 K392 E396 W399 N403	W68 N72 S75 G76 T77 T81 W110 N114 D118 W157 R164 K166 D196 W199 G207 N209 V247 T248 G249 W283 N287 A290 K318 E322 W325 N329

External links

PDB	RCSB:7n9h, PDBe:7n9h, PDBj:7n9h
PDBsum	7n9h
PubMed	35767952
UniProt	P52292\|IMA1_HUMAN Importin subunit alpha-1 (Gene Name=KPNA2)

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