Structure of PDB 7n9g Chain C

Receptor sequence
>7n9gC (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
KWEMERTDITMKHKLVYEGVWTVAVKTEVEEFLKEAAVMKEIKHPNLVQL
LIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH
RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAFPIKWTAPESLAYNKF
SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPE
KVYELMRACWQWNPSDRPSFAEIHQAFETMFQE
3D structure
PDB7n9g Imatinib can act as an Allosteric Activator of Abl Kinase.
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STI C A356 V357 L359 L360 A452 E481 G482 P484 V487 A76 V77 L79 L80 A167 E196 G197 P199 V202
BS02 1N1 C A288 M309 V318 T334 F336 M337 T338 G340 L389 A399 D400 F401 A24 M39 V48 T54 F56 M57 T58 G60 L109 A119 D120 F121
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7n9g, PDBe:7n9g, PDBj:7n9g
PDBsum7n9g
PubMed34774565
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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