Structure of PDB 7mx3 Chain C

Receptor sequence
>7mx3C (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
SGAPAPLVSIEENQELVGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMA
SLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQAPRPWP
LLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLST
FQGGSQSLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTE
PSLVYEAVCNRQNRPSLAELPQGPETPGLEGLKELMQLCWSSEPKDRPSF
QECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSS
3D structure
PDB7mx3 Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
ChainC
Resolution3.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZOV C K50 M64 T94 F96 M97 G100 S101 L149 A159 K35 M49 T79 F81 M82 G85 S86 L134 A144
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7mx3, PDBe:7mx3, PDBj:7mx3
PDBsum7mx3
PubMed34811356
UniProtQ9Y572|RIPK3_HUMAN Receptor-interacting serine/threonine-protein kinase 3 (Gene Name=RIPK3)

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