Structure of PDB 7mqk Chain C

Receptor sequence
>7mqkC (length=260) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
IPHTHAHLVDAFQALGIRAGQALMLHASVKAVGAVMGGPNVILQALMDAL
TPDGTLMMYAGWQDIPDFIDSLPDALKAVYLEQHPPFDPATARAVRENSV
LAEFLRTWPCVHRSANPEASMVAVGRQAALLTANHALDYGYGVESPLAKL
VAIEGYVLMLGAPLDTITLLHHAEYLAKMRHKNVVRYPCPILRDGRKVWV
TVEDYDTGDPHDDYSFEQIARDYVAQGGGTRGKVGDADAYLFAAQDLTRF
AVQWLESRFG
3D structure
PDB7mqk Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa.
ChainC
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.81: aminoglycoside N(3)-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIS C Y64 D72 E123 Y146 D170 H176 T212 G213 Y59 D67 E118 Y141 D165 H171 T207 G208
BS02 COA C H31 S33 V34 K35 P44 Y64 E102 N103 S104 V105 F109 A167 P168 T171 T173 H26 S28 V29 K30 P39 Y59 E97 N98 S99 V100 F104 A162 P163 T166 T168
Gene Ontology
Molecular Function
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046353 aminoglycoside 3-N-acetyltransferase activity
GO:0120225 coenzyme A binding
Biological Process
GO:0016999 antibiotic metabolic process
GO:0046356 acetyl-CoA catabolic process
GO:0046677 response to antibiotic
GO:0071236 cellular response to antibiotic
GO:1901742 2-deoxystreptamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7mqk, PDBe:7mqk, PDBj:7mqk
PDBsum7mqk
PubMed35921328
UniProtP29808|AACC3_PSEAI Aminoglycoside N(3)-acetyltransferase III (Gene Name=aacC3)

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