Structure of PDB 7mos Chain C

Receptor sequence
>7mosC (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]
KKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH
KATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLF
EFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIV
LAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPG
TGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAV
VLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRN
VARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPE
YMEKIKQRLFENLRMLPH
3D structure
PDB7mos Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
ChainC
Resolution1.704 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C D177 H179 D265 D169 H171 D257
BS02 CA C F188 T191 V194 Y223 F180 T183 V186 Y215
BS03 CA C D175 D177 H179 S198 F199 D167 D169 H171 S190 F191
BS04 ZLV C P30 D100 H141 H142 G150 F151 H179 F206 L272 G302 Y304 P22 D92 H133 H134 G142 F143 H171 F198 L264 G294 Y296
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:7mos, PDBe:7mos, PDBj:7mos
PDBsum7mos
PubMed34091041
UniProtQ92769|HDAC2_HUMAN Histone deacetylase 2 (Gene Name=HDAC2)

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