Structure of PDB 7m8i Chain C

Receptor sequence
>7m8iC (length=529) Species: 9606 (Homo sapiens) [Search protein sequence]
LDVVVENNLDIDGFGACEGTLACSTCHLIEDHIYEKLTDEENDMLDLAYG
LTDRSRLGCRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQ
ELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHR
GHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALK
KKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNF
LHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQK
IYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL
LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETL
RLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERY
NPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLV
ETLTQEDIKMVYSFILRPGTSPLLTFRAI
3D structure
PDB7m8i Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin.
ChainC
Resolution2.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.15.4: steroid 11beta-monooxygenase.
1.14.15.5: corticosterone 18-monooxygenase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004507 steroid 11-beta-monooxygenase activity
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0047783 corticosterone 18-monooxygenase activity
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0002017 regulation of blood volume by renal aldosterone
GO:0003091 renal water homeostasis
GO:0006629 lipid metabolic process
GO:0006694 steroid biosynthetic process
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0006705 mineralocorticoid biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0016125 sterol metabolic process
GO:0032342 aldosterone biosynthetic process
GO:0032870 cellular response to hormone stimulus
GO:0034650 cortisol metabolic process
GO:0034651 cortisol biosynthetic process
GO:0035865 cellular response to potassium ion
GO:0055075 potassium ion homeostasis
GO:0055078 sodium ion homeostasis
GO:0071375 cellular response to peptide hormone stimulus
GO:0140647 P450-containing electron transport chain
GO:1901615 organic hydroxy compound metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7m8i, PDBe:7m8i, PDBj:7m8i
PDBsum7m8i
PubMed34015331
UniProtP10109|ADX_HUMAN Adrenodoxin, mitochondrial (Gene Name=FDX1);
P19099|C11B2_HUMAN Cytochrome P450 11B2, mitochondrial (Gene Name=CYP11B2)

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