Structure of PDB 7m66 Chain C

Receptor sequence
>7m66C (length=360) Species: 1351 (Enterococcus faecalis) [Search protein sequence]
NSRFYQMSPEERLASLLNEGQISADTKKEFENTALSSQIANHMIENQISE
TEVPMGVGLHLTVDETDYLVPMATEEPSVIAALSNGAKIAQGFKTVNQQR
LMRGQIVFYDVADPESLIDKLQVREAEIFQQAELSYPSIVKRGGGLRDLQ
YRAFDESFVSVDFLVDVKDAMGANIVNAMLEGVAELFREWFAEQKILFSI
LSNYATESVVTMKTAIPVSRLSKGSNGREIAEKIVLASRYASLDPYRAVT
HNKGIMNGIEAVVLATGNDTRAVSASCHAFAVKEGRYQGLTSWTLDGEQL
IGEISVPLALATVGGATKVLPKSQAAADLLAVTDAKELSRVVAAVGLAQN
LAALRALVSE
3D structure
PDB7m66 Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor.
ChainC
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.9: acetyl-CoA C-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C T343 E347 T333 E337
BS02 CA C D158 L159 D148 L149
Gene Ontology
Molecular Function
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0015936 coenzyme A metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7m66, PDBe:7m66, PDBj:7m66
PDBsum7m66
PubMed37012403
UniProtA0A4U3MLJ4

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