Structure of PDB 7m5b Chain C

Receptor sequence
>7m5bC (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
SASEEQVAQDTEEVFRSYVFYRHQQEQEAPADPEMVTLPLQPSSTMGQVG
RQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINW
GRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHSIARWIAQRG
GWVAALNLCN
3D structure
PDB7m5b Structural basis of BAK activation in mitochondrial apoptosis initiation.
ChainC
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C Y89 E92 Y64 E67
BS02 peptide C I81 I85 Y89 E92 F93 M96 I114 S117 L118 N124 W125 G126 R127 V129 A130 F134 N182 L183 C184 N185 I56 I60 Y64 E67 F68 M71 I89 S92 L93 N99 W100 G101 R102 V104 A105 F109 N157 L158 C159 N160
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7m5b, PDBe:7m5b, PDBj:7m5b
PDBsum7m5b
PubMed35017502
UniProtQ16611|BAK_HUMAN Bcl-2 homologous antagonist/killer (Gene Name=BAK1)

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