Structure of PDB 7m33 Chain C

Receptor sequence

>7m33C (length=573) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

FSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAIDDMKAGA
FTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHL
LTMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFL
TMGFLISWKLTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRV
LESVSGVRVIRAYVQETNDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKL
LVGASYLIGLGYGAFLVFRNELTLGELVSFNVYLGMMIWPMFAIGELINV
MQRGNASLDRVNETLSYETDVTDPKQPADLKEPGDIVFSHVSFTYPSSTS
DNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGEGSITFSGVP
IQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAEA
HFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDQS
LSAVDAKTEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIA
ERGTHQELLANNGWYREQYERQQ

3D structure

• PDB: 7m33 Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter.
• Chain: C
• Resolution: 3.55 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	C	Y346 S348 T373 G374 S375 G376 K377 T378 T379 Y388 Q500	Y345 S347 T372 G373 S374 G375 K376 T377 T378 Y387 Q499
BS02	HT1	C	E246 F293 E297	E245 F292 E296
BS03	HT1	C	E33 F83 F134	E32 F82 F133

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0046677 response to antibiotic
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7m33, PDBe:7m33, PDBj:7m33
• PDBsum: 7m33
• PubMed: 34931066
• UniProt: O07550|YHEI_BACSU Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI (Gene Name=yheI)