Structure of PDB 7m1z Chain C

Receptor sequence

>7m1zC (length=422) Species: 1351 (Enterococcus faecalis) [Search protein sequence]

HMLLERPQQKKNSRFYQMSPEERLASLLNEGQISADTKKEFENTALSSQI
ANHMIENQISETEVPMGVGLHLTVDETDYLVPMATEEPSVIAALSNGAKI
AQGFKTVNQQRLMRGQIVFYDVADPESLIDKLQVREAEIFQQAELSYPSI
VKRGGGLRDLQYRAFDESFVSVDFLVDVKDAMGANIVNAMLEGVAELFRE
WFAEQKILFSILSNYATESVVTMKTAIPVSRLSKGSNGREIAEKIVLASR
YASLDPYRAVTHNKGIMNGIEAVVLATGNDTRAVSASCHAFAVKEGRYQG
LTSWTLDGEQLIGEISVPLALATVGGATKVLPKSQAAADLLAVTDAKELS
RVVAAVGLAQNLAALRALVSEGIQKGHMALQARSLAMTVGATGKEVEAVA
QQLKRQKTMNQDRALAILNDLR

3D structure

PDB

7m1z Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor

Chain

Resolution

2.27 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.9: acetyl-CoA C-acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MEV	C	E86 R257 T260 N267	E87 R258 T261 N268
BS02	NAP	C	S148 R152 V177 K178 A180 M181 G182 A183 N184 N213 V323 G325	S149 R153 V178 K179 A181 M182 G183 A184 N185 N214 V324 G326
BS03	CA	C	P87 L379 R382	P88 L380 R383
BS04	CA	C	D158 L159	D159 L160
BS05	NAP	C	E86 K263 H376 N409 Q410	E87 K264 H377 N410 Q411
BS06	CA	C	Q31 I32	Q32 I33

Gene Ontology

	Molecular Function
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

	Biological Process
GO:0015936	coenzyme A metabolic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7m1z, PDBe:7m1z, PDBj:7m1z
PDBsum	7m1z
PubMed
UniProt	Q835L3

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