Structure of PDB 7m0l Chain C

Receptor sequence
>7m0lC (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
DPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDD
DVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQ
VTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLA
DFGISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGIT
AIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVT
LTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN
3D structure
PDB7m0l Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
ChainC
Resolution2.43 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 A164 T175
Catalytic site (residue number reindexed from 1) D133 K135 A137 N138 D151 A160 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YK4 C L23 Y28 V31 A44 M91 E92 C94 G97 D101 L144 F156 L19 Y24 V27 A40 M87 E88 C90 G93 D97 L140 F152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7m0l, PDBe:7m0l, PDBj:7m0l
PDBsum7m0l
PubMed33859804
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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