Structure of PDB 7ltx Chain C

Receptor sequence
>7ltxC (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLL
DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ
HVKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY
DGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELI
IEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM
3D structure
PDB7ltx Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP C G719 S720 G721 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844 G20 S21 G22 V27 A44 K46 M91 M94 C98 D138 R142 N143 L145
BS02 MG C N842 D855 N143 D156
BS03 YFA C A743 K745 I759 E762 A763 M766 L777 L788 M790 D855 F856 A44 K46 I60 E63 A64 M67 L78 L89 M91 D156 F157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ltx, PDBe:7ltx, PDBj:7ltx
PDBsum7ltx
PubMed35378251
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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