Structure of PDB 7lpp Chain C

Receptor sequence
>7lppC (length=729) Species: 235443 (Cryptococcus neoformans var. grubii H99) [Search protein sequence]
PPEVSPVTGNPVSPHYIHSSTLHFQDVNGRSLVLRGVNLSGSAKHPNNQP
SHIREGFWETAEAGKGDFINKPLNLDDGSADLHLARLKAWGYNLLRYVFT
WESLEHAGPKEYDYAYMDYIIAVLRKCKEWGFRVFMDPHQDVWSRFTGGS
GAPLWTLYACGIDPYHLTATAAAYLHCEWPSAESPKPQDFPAMIWGTNYT
HLANQTIWTFFFAGKTYAPKCIIDGKNIQDFLQDHFIDAVGELAKRIAEE
AGDLLDECVIGWDSINEPGEGLIGCKDLAVIPAEQQLKKGPSPTPIEGMR
LGMGEAQDVQAWNFGPMGPYRGSRQTIDPKGVKLWLSKEDDVKRGSGKWG
WTRGKEWALGTCIWAHHGVWEIATSTLLRPDYFSTLPTNPGHQVDFVDDF
WALHWLAYSSRIRLHHPESIHFIQAPVLRQPPKLPESFLKGRACSSPHFY
DGLTLMTKHWNWFNADAIGVIRKKYWSIVQAVRIGEGPIRKMIQGELAVL
KQDTIDILGNYPTLVGEIGIPYDMDDKKAYGYVDGGRGEGDYSSQQKAMD
CSMNACDGPNCLNYAIWNYVPDNVHEWGDNWNGEDLSLWSVDDKELRPSP
SVIDSGDFSPTLILDGSRAVAAFCRPYPVATVGIPERIDFDITSTKFKYA
VRVRADDIANEQVYTEIYLPFVHYAASLNAAQLSLDVTIVASHGRVEIQG
QTLRWWYPVPGTGEEVYTIEVQRNGGALR
3D structure
PDB7lpp Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents.
ChainC
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YAG C W198 E270 V430 L431 H451 Y453 W570 E587 W195 E267 V427 L428 H448 Y450 W567 E584
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0050295 steryl-beta-glucosidase activity
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0016042 lipid catabolic process
GO:1901136 carbohydrate derivative catabolic process
GO:1904462 ergosteryl 3-beta-D-glucoside catabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lpp, PDBe:7lpp, PDBj:7lpp
PDBsum7lpp
PubMed34620873
UniProtJ9W473

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